Volumetric differences in hippocampal subfields and associations with clinical measures in myalgic encephalomyelitis/chronic fatigue syndrome, by Kiran Thapaliya, Donald Staines, Sonya Marshall- Gradisnik, Jiasheng Su, Leighton Barnden in Journal of Neuroscience Research March 31, 2022 “The hippocampus is a small, curved formation in the brain that plays an important role in the limbic…
ME/CFS & Long COVID patients have similar symptoms & quality of life This Australian study compared 61 patients with ME/CFS with 31 patients with Long Covid (aka Post COVID-19 condition- PCC) and found few differences in symptoms between the two groups. They say: “this publication documents the profound and widespread illness burden experienced by…
Urinary biomarkers for ME/CFS? Although urine would be an easy sample to collect from patients this study found that research into its use as a biomarker for ME/CFS was inconsistent. Studies were limited in size, susceptible to variables, used differing methodologies and participant criteria. The authors thought urine could still prove to be a…
Biomarkers for ME/CFS: a systematic review Australian researchers found 101 key studies in ME/CFS that varied in efficacy, quality, and potential to be developed into a diagnostic biomarker. Most were blood-based and measured a range of dysfunction. “Many of these biomarkers were studied in isolation but may be part of a complex multidisciplinary process…
fMRI distinguishes between two classes of ME/CFS Australian researchers have discovered that patients diagnosed using 2 different criteria, International Consensus Criteria (ICC) and the Fukuda criteria, have different brain activity. The main difference between the 2 criteria is that post-exertional malaise (PEM) is not an essential symptom for diagnosis. They used Functional magnetic resonance…
Understanding Myalgic Encephalomyelitis – Myalgic Encephalomyelitis and Long COVID have overlapping presentation Dr Sonya Marshall-Gradisnik and Dr Natalie Eaton-Fitch from Griffith University, on the Gold Coast in Australia, say there is a significant overlap in symptoms and possibly the underlying processes in ME and LC. Lessons should be learned from understanding ME: An important…
TRPM3 dysfunction in post COVID-19 condition and ME/CFS patients Research from the NCNED in Australia, using their Electrophysiology ‘Patch Clamp’ technique, concludes: The results of this investigation suggest that post COVID-19 condition patients may have impaired TRPM3 ion channel function and provide further evidence regarding the similarities between post COVID-19 condition and ME/CFS. Impaired…
Impaired TRPM3-dependent calcium influx and restoration using Naltrexone in natural killer cells of myalgic encephalomyelitis/chronic fatigue syndrome patients, by Natalie Eaton-Fitch, Stanley Du Preez, Hélène Cabanas, Katsuhiko Muraki, Donald Staines & Sonya Marshall-Gradisnik in Journal of Translational Medicine volume 20, Article number: 94 (2022) Research abstract: Background: Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a…
Long COVID overlap with ME/CFS A group of researchers from around the world have joined together to analyse long COVID’s symptom overlap with ME/CFS. Highlights Serious side effects and post-infection sequelae have been reported in SARS-CoV-2-infected patients after acute disease phase. Long-COVID patient characteristics and symptoms were compared to myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)….
Characterization of IL-2 stimulation and TRPM7 pharmacomodulation in NK Cell cytotoxicity and channel Co-Localization with PIP2 in Myalgic Encephalomyelitis/ Chronic Fatigue Syndrome patients, by Stanley Du Preez , Natalie Eaton-Fitch, Helene Cabanas, Donald Staines and Sonya Marshall-Gradisnik in Int. J. Environ. Res. Public Health 2021, 18(22), 11879; [doi.org/10.3390/ijerph182211879] 12 Nov 2021 (This article belongs to…